SPECIAL EDITION: Full Guide to Cannabis as Medicine

Cannabis as Medicine

Humans have been using cannabis for thousands of years.

The oldest known written record of cannabis use comes from the Chinese Emperor Shen Nung in 2727 BC. The early Chinese surgeon Hua Tuo (c. AD 140-208) is credited with being the first recorded person to use cannabis as an anesthetic. He reduced the plant to powder and mixed it with wine for administration prior to performing surgery. (1) Through details captured in hieroglyphics, historians have noted that ancient Egyptians also used cannabis. In India, bhang, a drink made with raw cannabis, is considered to be an overall wellness beverage. Steam baths in the Middle East also show evidence of using cannabis to help with inflammation. (2)

1. James L. Butrica, “The Medical Use of Cannabis Among the Greeks and Romans,” Journal of Cannabis Therapeutics 2 no. 2 (2002), 51.

2. Ibid.

In the United States, cannabis tinctures were considered to be an everyday health aid and were widely available at pharmacies until the 1930s, when the plant became criminalized as part of Prohibition, and its healing potential was largely forgotten. In recent years, thanks to the courageous efforts of many activists, more and more work is being done to tap into the plant’s potential.

Terpenes

Terpenes are the fragrant oils that give cannabis its aromatic diversity. These oils, secreted in the flower’s sticky resin glands, also appear in many other herbs, fruits, and plants. They play a significant role in the therapeutic and medicinal use of cannabis by creating subtle differences in effects across different strains. If cannabinoids are a ship’s engine, the terpenes can be thought of as the rudder. At Papa & Barkley, we maintain the terpene profile found naturally in the plant and do not add terpenes back into our products (a process known as reterpening). As always, our philosophy is: why mess with a good thing?

The Benefits of Terpenes

Linalool

COMMONLY FOUND IN: Lavender

Anxiety relief, Sedation, Pain relief

Myrcene

COMMONLY FOUND IN: Mango, lemongrass, thyme, hops

Relieves muscle tension, Anti-inflammatory, Produces a soothing effect

Limonene

COMMONLY FOUND IN: Fruit rinds, peppermint

Antifungal, Anti-bacterial, Anti-carcinogen, Dissolves gallstones, Enhances mood

Can be used to treat gastrointestinal complications, heartburn, and depression

Caryophyllene

COMMONLY FOUND IN: Black pepper, cloves, cotton

Gastroprotective, Anti-inflammatory

Pinene

COMMONLY FOUND IN: Pine needles, rosemary, basil, parsley, dill

Alertness, Memory retention, Antiseptic, Counteracts some THC effects

Source: “What Are Cannabis Terpenes and How Do They Affect You?,” https://www.leafly.com/news/cannabis-101/infographic-what-are-cannabis-terpenes-and-how-do-they-affect-you

Cannabinoids

Phytocannabinoids, or cannabinoids, are the natural chemical compounds produced by cannabis flowers that provide the plant with natural protection. There are over a hundred cannabinoids that are unique to cannabis. Cannabinoids are found in everyday plants, too! You may already be familiar with echinacea, used to soothe a sore throat and combat cold and flu symptoms.

Cannabinoids closely resemble natural compounds produced by our own bodies that are called endocannabinoids. These molecules bind to the body’s cannabinoid receptors, which were first discovered in 1988; this network of endocannabinoids and the receptors that regulate bodily function is called the endocannabinoid system (ECS).

Like endocannabinoids, each cannabinoid has a different composition and influence on the cannabinoid receptors in the endocannabinoid system, which provides the opportunity to successfully treat a wide variety of ailments and provide relief from an array of symptoms. Early research indicates that each cannabinoid has unique medicinal properties.

The concentration of cannabinoids varies with each cannabis strain. Knowing the percentage of certain cannabinoids in your cannabis and/or cannabis-infused products can help you understand how the plant will affect your body, allowing you to choose the most effective product for your ailments and symptoms.

Look for miligram counts of cannabinoids on your products to understand their potency. The higher the milligram count of cannabinoids, the greater the efficacy of the product. This is true of topicals, tinctures, edibles, and even flower strains.

The milligram count of cannabinoids works similarly to other over-the-counter medicines; Tylenol, for example, comes in regular strength of 325mg of acetaminophen in each pill and extra strength of 500mg of acetaminophen in each pill. In the same way, a 5mg (THC or CBD) count of cannabinoids is a lighter dose than a 30mg (THC or CBD) count of cannabinoids.

Primary Cannabinoids:

THC (tetrahydrocannabinol)

PSYCHOACTIVE

USED FOR: Acute pain relief, Stress, Appetite, Sleep

• most prevalent cannabinoid

CBD (cannabidiol)

NON-PSYCHOACTIVE

USED FOR: Anxiety, Inflammation, Epilepsy, Arthritis

• major phytocannabinoid, making up almost 40% of plant extract

THCa (tetrahydrocannabinolic acid)

NON-PSYCHOACTIVE

USED FOR: Anti-inflammatory, Neuroprotective, Anti-nausea, Appetite

• Psychoactive, but far less than THC for most people; non-psychoactive for some

• Delivers the same healing properties of THC, without the psychoactivity

• THCa is the precursor to activated THC

• THCa converts to psychoactive THC when heated

CBDa (cannabidiolic acid)

NON-PSYCHOACTIVE

USED FOR: Anti-inflammatory, Anti-nausea, Antioxidant

• Similar to THCa, CBDa is the precursor to activated CBD

CBN (cannabinol)

NON-PSYCHOACTIVE

USED FOR: Pain management, inflammation, insomnia

• CBN is a breakdown product of THCa

• CBN is widely known for its sedative effect

CBG (cannabigerol)

NON-PSYCHOACTIVE

USED FOR: Muscular disorders, Skin conditions, Inflammation, Anxiety

• Early studies suggest that CBG is an analgesic and can aid with eyesight, muscle contractions, psoriasis, and depression (3)

3. Leafly, https://www.leafly.com/news/cannabis-101/what-is-cbg-cannabinoid

Right Ratio

Each person’s body and endocannabinoid system is unique, with different needs and receptors. We believe that cannabis is not one-size-fits-all. We also believe— thanks to research—that optimal therapeutic efficacy requires the use of both CBD, the non-psychoactive compound in cannabis, and THC, its psychoactive component. Papa & Barkley offers a suite of products in different ratios, allowing you to select the best ratio for your therapeutic needs.

You can find the ratio of CBD to THC on the product label. The larger the amount of THC to CBD, the more THC-rich the product is, and vice versa.

1:3 CBD : THC

Good starting point for most people seeking pain relief

1:1 CBD : THC

Balanced holistic approach

3:1 CBD : THC

Often ideal for ongoing inflammation and other conditions

Plants with Healing Cannabinoids

Cannabaceae

Cannabis

Echinacea

Coneflower

Helichrysum umbraculigerum

Woolly Umbrella Helichrysum

Piper nigrum

Black Pepper

Radula Marginata

Liverwort

Theobroma cacao

Chocolate

Acmella oleracea

Electric Daisy

All illustrations by Nyssa Collins - Cannabis as Medicine

Your Endocannabinoid System (ECS)

The endogenous cannabinoid system, also known as the endocannabinoid system (ECS), can be thought of as the air traffic control center for the body. It controls physiological processes, including appetite, pain sensation, mood, and memory. The ECS consists of two primary cannabinoid receptors: CB1 receptors (most abundant in the central nervous system) and CB2 receptors (more abundant in the cardiovascular, gastrointestinal, and peripheral nervous systems).

The Receptors

Cannabinoids and naturally occurring endocannabinoids affect the user by interacting with the CB1 and CB2 receptors, binding with the receptors much like a handshake between two people. The first endocannabinoid was discovered in 1992 and named anandamide (after the Sanskrit word for “bliss”). Anandamide appears within the brain and binds to CB1 receptors; it is known as “human THC” and functions as the body’s own antidepressant, contributing to our mental health and providing pain relief (especially after exercise), as well as appetite and memory regulation.

Cannabinoids and endocannabinoids bind to the same CB receptors but interact with the ECS in the body in many different ways to produce various physiological, medicinal, and therapeutic effects. These interactions are what drive modern research into cannabinoids and will lead to future medical discoveries as research on the cannabis plant continues to grow.

The physiological effects of cannabinoids vary depending on the location of the cannabinoid receptors that they stimulate. These receptors are common in our limbic system (the part of the brain that affects memory, cognition, and psychomotor performance) and our mesolimbic pathway (associated with feelings of reward), and are also widely distributed in areas governing pain perception.

Different ailments and conditions respond to different cannabinoids. Someone with chronic inflammation, for example, may benefit from CBD, as it is one of the strongest anti-inflammatory agents found in nature. On the other hand, THC is one of the strongest analgesics (painkillers). Insomnia sufferers would also benefit from THC because it helps calm the mind.

Entourage Effect

The entourage effect — the idea that molecules that occur together in nature interact in useful ways — definitely applies to cannabinoids and terpenes. Terpenes are molecular compounds that are naturally found in plants and insects, manifest themselves most often in the forms of natural oils, and are accompanied by a distinct aroma and viscosity. Terpenes and cannabinoids (such as CBD and THC) work together to maximize benefits in the body. Lab and patient-based studies reveal that while CBD or THC can work alone for some symptoms, they can often create better outcomes in combination. Specific ratios, especially with naturallyoccurring terpenes, have the potential to cause even better effects. The entourage effect is one of the leading theories influencing cannabis research worldwide.

Bioavailability

Bioavailability refers to the absorption of cannabinoids in the body. This absorption varies by body site and delivery method (i.e., topical, sublingual, ingestion, or inhalation). Inhaling 10 mg of CBD through a vape is not equivalent to ingesting 10 mg of CBD in a tincture. While smoking is an effective delivery method for many, the heat actually burns off cannabinoids and other phytonutrients, reducing the available cannabinoids. When taking a tincture sublingually (under the tongue), precise dosing is needed, as all the cannabinoids are absorbed by the body. With topicals, such as balms and body oils, natural lipids like coconut oil absorb rapidly through the skin, making them ideal substrates.

Cannabis For You

Choosing the Right Product

Selecting the best product is based on a number of parameters. Consider the following when deciding on the best product for you:

• The ailment or indication from which you’re seeking relief.

• Does your condition require targeted or whole-body relief?

• Your preferred delivery method, taking into account onset time and duration.

• The potency, CBD to THC ratio, and level of psychoactivity that you’d like.

Will these products get me “high,” or do they cause psychoactivity?

Psychoactivity is an important consideration when selecting a product. While psychoactivity is therapeutic and, for example, an important factor for those seeking restful sleep, we recognize psychoactivity can be inhibiting during the work day.

In much the same way that drinking a bottle of NyQuil might make you feel “high,” consuming too much cannabis can cause major dysphoria. When taken responsibly, you can avoid unintended psychoactivity.

Here Are Some Helpful Tips

• Use a topical for localized effect or if you need to avoid psychoactivity

• If ingesting or smoking, start with a small dose and increase the dosage in 5mg increments. Note the onset time and determine whether you are getting the desired effect

• Ingest or take CBD sublingually to counteract any unintended paranoia, anxiety, or psychoactivity from THC

• Look for products with THCa or lower ratios of THC to minimize psychoactivity

Delivery Methods

Papa & Barkley offers different delivery systems, each featuring varying cannabinoid ratios, to provide customized types and amounts of relief.

Topically

Topicals provide relief by letting cannabinoids penetrate the skin and interact with our receptors to reduce pain, swelling, and inflammation. Results can be felt within a few minutes, and relief can last anywhere from two to four hours. Fatty tissues can also store CBD and provide ongoing relief. Most importantly, the cannabinoids do not reach the bloodstream, so pain relief is localized where applied, with no psychoactivity.

Orally

When taking tinctures, capsules, or edibles orally, the cannabinoids are metabolized in the stomach like a food or beverage. The cannabinoids enter the bloodstream directly and immediately travel to the brain, where they bind to cannabinoid receptor cells. When ingested, THC becomes 11-hydroxy-tetrahydrocannabinol, a cannabinoid that is five to ten times more psychoactive than THC itself. CBD and THCa, however, can be ingested without concern for psychoactive effects. Ingestion is one of the best ways to absorb CBD because it brings out its strong anti-inflammatory properties. This method has similar mind and body effects to inhaling cannabis through smoking or vaporization. Effects are usually felt within 15 to 45 minutes and last two to three hours.

Vaping

Vaping allows the user to inhale the cannabinoids from the cannabis product (oil, wax, shatter), releasing them directly into the bloodstream. Depending on the THC level and proximity to the brain, the user can experience psychoactivity within minutes.

Transdermally

Patches are a transdermal delivery system, meaning that the cannabinoids penetrate all layers of the skin to reach your bloodstream. This affects pain and inflammation throughout the body, regardless of the pain’s location. Transdermal patches release slowly, so they deliver the full cannabinoid content over the course of 12 hours.

The low doses of cannabinoids do not cause psychoactivity, but they do represent a therapeutic dose of cannabinoids for users suffering from chronic pain and inflammation. Effects are usually felt within 30 to 45 minutes and last for 12 hours.

Our Production Process

We do not use solvents.

We do not add distillates.

We let the plant do the work.

Lipid Infusion

Our main method of extraction is our proprietary lipid infusion technique, which is used in developing all our topical and tincture products. This is an all-natural and solvent-free process, meaning chemicals are never introduced.

In this process, we soak our premium cannabis plants in a simple lipid (fat) base such as coconut oil, fractionated coconut oil, or MCT oil, then add heat and pressure using our pressurized lipid infusion cooking process. During this cooking process, the cannabinoids are absorbed (infused) into the lipid base. Our unique approach maintains all of the original terpenes or cannabinoids and phytonutrients, unlike many other extraction methods, such as CO2 or butane, and preserves more cannabinoids than other leading brands. We perform this process on THC- and CBD-rich flowers. The resulting oils are blended to achieve our different ratios.

Fresh-Pressed Rosin

Our Releaf Patches are produced from fresh-pressed rosin oil. The rosin process involves pressing cannabis between two heated metal plates to produce the all-natural extract; this concentrated oil has a similar consistency to tree sap.

The resulting extract is typically very potent (over 60% cannabinoids) and, again, we maintain the plant’s full cannabinoid and terpene profile. We never add ethanol (a process called winterization), which is commonly used to produce a clear, chlorophyll- and phytonutrientdeficient product. All our products are earthy in color because the chlorophyll and valuable phytonutrients and natural plant matter still exist in the extracts. These rosin extracts are then combined to achieve our four different ratios (1:3, 1:1, 3:1 and CBD only).

Supporting Ingredients

Cannabis is a powerful plant, made even more so when combined with other healing plants and natural ingredients, such as the following:

Lavender

Known to promote blood circulation and aid in overall pain relief, including sore and tense muscles, muscle aches, rheumatism, sprains, and backaches.

Eucalyptus oil

Used for healing wounds, ulcers, burns, cuts, and sores. It is also an effective salve for insect bites.

Tea tree oil

Well known for its powerful antiseptic properties and ability to treat wounds.

Beeswax

An antibacterial that serves as an effective barrier and sealer for the skin. It holds in moisture, protects the skin, and is good for reducing swelling.

Peppermint oil

Relieves sore muscles when used topically, provides a cooling sensation, and has a calming effect on the body.

Vitamin E oil

Provides the skin with necessary moisture and antioxidants for intense healing.

Oleic acid

Has potent moisturizing qualities and is high in antioxidants to help repair cell damage; is also an anti-inflammatory.

Our Infused Oils:

Coconut oil

An excellent moisturizer that is also antibacterial and antifungal. It can penetrate the skin and is praised for its anti-aging properties.

Medium chain triglycerides (MCT) oil

Known for its antimicrobial, antibacterial, and antiviral properties. This oil is rapidly metabolized by the body.

Our Products

We believe that cannabis is individualized medicine. Different bodies, different ailments, and different conditions require different ratios of cannabinoids. Simply look for the ratio on each package and select the level of THC to CBD that’s right for you.

THC Rich

Good for acute aches and pains.

THCa 1:1 Balanced

Good for acute aches and pains with no psychoactivity. This product, made from fresh-pressed rosin oil, utilizes THCa, which is the cannabinoid found in raw cannabis leaves. THCa is the precursor to activated THC (THCa converts into THC when heated).

THC 1:1 Balanced

Good for aches, pains, and ongoing inflammation with little to no psychoactivity.

CBD Rich

Good for ongoing pain and inflammation.

CBD Dominant

Good for full body wellness. Ideal for newer users and those sensitive to THC.

Releaf Balm

Releaf Balm brings a breakthrough approach and formula that is tougher on pain. This formula delivers hours of pain relief in an all-natural, botanical pain balm. It is infused via our proprietary lipid infusion process and is unmatched for potency and terpene content. Each 50ml jar contains more than 400mg of cannabinoids, activated either by the 3:1 or 1:3 CBD:THC “right ratio.” It is not psychoactive and will not show up on a drug screen.

CBD:THC RATIOS: 1:3 , 3:1

DOSE: One nickel-sized scoop

TOTAL CANNABINOIDS: 3:1 15ml : 120mg 3:1 50ml : 600mg 1:3 15ml : 200mg 50ml : 600mg

DURATION: 2-3hrs.

EXTRACTION: Lipid Infusion

DIRECTIONS: Apply balm liberally and gently massage over affected area until completely absorbed. Repeat three or more times daily as needed.

Releaf Patch

Our Releaf Patch provides 12 hours of full body relief via a transdermal delivery system. Thanks to its slow-release formula, activated with more than 30mg of cannabinoids per patch in a variety of CBD:THC ratios, the continuous low doses of cannabinoids do not cause psychoactivity, but provide a therapeutic dose of cannabinoids for users suffering from chronic pain and inflammation. Effects are usually felt within 30 to 45 minutes and last for 12 hours.

CBD:THC RATIOS: 1:3, 1:1, 3:1, CBD Only

TOTAL CANNABINOIDS: 30mg per patch

DOSE: 1 patch

DURATION: Onset: 15min. - 1hr. Duration: 12hrs.

EXTRACTION: Fresh-pressed rosin

DIRECTIONS: Apply to a clean, dry, flat area. Open the sachet, remove the liner, and place patch on the skin, sticky side down.

Releaf Capsules

Our 100% solvent-free whole-plant Releaf Capsules provide holistic and discrete delivery for those in need of strong pain-relieving and anti-inflammatory properties. THC and CBD cannabinoids enter the bloodstream and may provide psychoactivity with the THC-rich 3:1 ratio. The 1:30 CBD-rich capsule is great to take daily to ease whole-body aches and inflammation.

CBD:THC RATIOS: 1:3, 30:1

TOTAL CANNABINOIDS: 30 capsules: 900mg 7 capsules: 210mg

DOSE: 1 capsule

DURATION: Onset: 60-90min.

EXTRACTION: Lipid Infusion

DIRECTIONS: Start with taking 1 capsule on a full stomach. Repeat as needed.

Releaf Tincture

The Releaf Tincture provides a holistic, discrete and flexible option for those in need of strong pain-relieving and anti-inflammatory properties. Brewed using our proprietary lipid infusion process, the tincture infuses whole-plant cannabis directly into MCT and fractionated coconut oil, creating an extremely absorbent and highly potent formula. Consult the dosing instructions on the label for optimal results and stick to the “low and slow” method of titrating cannabinoids.

CBD:THC RATIOS: 1:3, 30:1 and 1:1 CBD:THCa

TOTAL CANNABINOIDS: 900mg in 30ml

IDEAL FOR: Acute Pain, Overall body relief

DOSE: 1/4 dropper

DURATION: 2-3hrs. Onset: 15-20min. sublingually; up to 60min. orally

EXTRACTION: Lipid Infusion

DIRECTIONS: Start with a .25ml dose under the tongue and hold for 15 seconds until absorbed to determine individual potency. Caution is suggested with higher THC varieties.

Releaf Soak

Releaf Soak brings the power of Papa & Barkley’s topical products into the relaxing atmosphere of a soaking bath. Made with Dead Sea salts imported from Israel, Releaf Soak allows you to relax your entire body with an all-encompassing, therapeutic soak infused with our 1 :3 CBD:THC “right ratio.” Releaf Soak is preferred by patients with conditions such as neuropathy, migraines, anxiety, muscle spasms, swelling, inflammation, and psoriasis.

CBD:THC RATIOS: 1:3

TOTAL CANNABINOIDS: 67mg

DOSE: 1 package

DURATION: 2-3hrs.

EXTRACTION: Lipid Infusion

DIRECTIONS: Traditional soak: Add half the contents of the jar to the bath or use the full amount for maximum effect. Use one-quarter to one-half of the jar for soaking hands and/ or feet, if desired. Soak for 15 to 20 minutes.

Releaf Body Oil

Releaf Body Oil is applied topically to allow for minimal friction and maximum cannabinoid exposure during a massage or as a remedy for inflamed or dry skin. Our Body Oil is excellent for acute pain, muscle recovery, and relaxation.

CBD:THC RATIOS: 1:3

TOTAL CANNABINOIDS: 900mg in 30ml

DOSE: 3 to 4 pumps per area

DURATION: Onset felt within 15min. Relief lasts for 2-3hrs.

EXTRACTION: Lipid Infusion

DIRECTIONS: Shake well. Apply oil liberally (3-4 pumps per body area) and massage over body from head to toe until the oil is completely absorbed.

Notes

Knowledge Center URL: papaandbarkley.com/knowledgecenter

If you ever have any questions or concerns about any of our products. please drop us a line at askpapa@papaandbarkley.com

Index

Cannabis

A plant genus that produces three species of flowering plants: Cannabis sativa, Cannabis indica, and Cannabis ruderalis. Cannabis has long been cultivated both for the production of hemp and medicine.

Flower

Flowers produce the resin that contains their active cannabinoids. Cannabis flowers are the hairy, sticky, crystal-covered bits that are harvested and dried to be used as medication.

Hemp

A fibrous product that can be produced from the male cannabis plant and can be used in the manufacture of rope, paper, beauty products, and a vast array of other products.

Terpenes

The fragrant oils that give cannabis its aromatic diversity. They play a significant role in the therapeutic and medicinal use of cannabis, by creating subtle differences in effects across different strains.

ECS

The endogenous cannabinoid system, or endocannabinoid system (ECS) for short, can be thought of as the air traffic control center for the body. The ECS consists of two primary cannabinoid receptors, CB1 receptors (most abundant in the central nervous system) and CB2 receptors (more abundant in the cardiovascular, gastrointestinal, and peripheral nervous systems).

Entourage Effect

The idea that molecules that occur together in nature interact in useful ways, which applies to cannabinoids and terpenes.

Bioavailability

The absorption of cannabinoids in the body. This absorption varies by body site and delivery method (i.e., topical, sublingual, ingestion, inhaling).

Vaping

A consumption method that heats either flowers or marijuana-infused oils to a temperature that produces a cannabinoid-laced vapor to inhale.

Smoking

A consumption method that combusts flowers with high heat to inhale the smoke produced; provides immediate effects and psychoactivity.

Topical

A consumption method that provides relief through cannabinoids penetrating the skin (our largest organ) and interacting with our receptors to reduce pain, swelling, and inflammation. Cannabinoids do not reach the bloodstream, so pain relief is localized where applied, with no psychoactivity.

Ingestion

A consumption method to take tinctures, capsules, or edibles orally; the cannabinoids are metabolized in the stomach like a food or beverage. The cannabinoids enter the bloodstream directly and immediately travel to the brain, providing longer lasting effects and psychoactivity.

Sublingual

A consumption method to orally take a tincture, capsule or edible under the tongue, which provides quicker absorption and effects.

Transdermal

A consumption method in which the cannabinoids penetrate all layers of the skin to reach your bloodstream. This affects pain and inflammation throughout the body, regardless of the pain’s location. Transdermal patches release slowly, so they deliver the full cannabinoid content over the course of 12 hours.

Lipid Infusion

An all-natural and solvent-free extraction process in which cannabis plants are soaked in a simple fat (lipid) base such as coconut oil, fractionated coconut oil, or MCT oil, then add heat and pressure using our pressurized lipid infusion cooking process. During this cooking process, the cannabinoids are absorbed (infused) into the lipid base.

Rosin

This extraction process involves pressing cannabis between two heated metal plates to produce the all-natural extract; this concentrated oil has a similar consistency to tree sap.

Duration

How long a product’s effects will last.

Onset

How long until a product’s effects are felt.

Psychoactive

The “high” effect produced by THC.

THC

The abbreviation for tetrahydrocannabinol. It is the most well-known and most abundantly available cannabinoid in marijuana plants. THC is also the component in marijuana that is responsible for the psychoactive effects, or the “high.” Research has shown THC to be an effective medical treatment for a range of conditions.

CBD

The abbreviation for cannabidiol, one of the at least 85 cannabinoids found in cannabis and the second only to THC when it comes to average volume. Recently, CBD has gained support for its use as a medical treatment as research has shown it effectively treats pain, inflammation, and anxiety without the psychoactive effects.

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

PlantMade

from PlantMade: A Wellness Guide to Cannabis

by Papa & Barkley

Contents

Who We Are

Our Philosophy

Cannabis as Medicine

Your Endocannabinoid System

Cannabis for You

Delivery Methods

Our Production Process

Supporting Ingredients

Our Products

Who We Are

Papa & Barkley is a team of caregivers, scientists, researchers, and designers on a mission to unlock the potential of the cannabis plant to improve people’s lives.

Our very first product joined traditional techniques with a dash of modern methods to create the only treatment that relieved the debilitating back pain of our founder’s elderly father, Papa. Today, with guidance from best-inclass research, we have crafted these artisanal formulas into our award-winning products, which are some of the most potent on the market.

We do not use solvents. We do not add distillates. We let the plant do the work.

Our Philosophy

When it comes to our products, we are committed to a whole-plant infusion process. “Whole-plant” means just what it sounds like—it’s using the whole plant! We use the cannabis flowers, leaves, and stems, instead of just one part of the plant or isolated components. You can see evidence of this process in the earthy green color of our products. You experience the “whole-plant” effect when inhaling cannabis smoke or vapor from the buds, as it is the experience most aligned with consuming cannabis as nature designed it.

We persistently strive to make products that are better for you, your family, and all your loved ones.

We do not use solvents. We do not add distillates. And we do not re-add terpenes. We let the plant do all the work! Our proprietary whole-plant infusion process captures the full cannabinoid profile and all cannabis phytonutrients and terpenes and allows us to use them in tandem with each other. This infusion process is completely solvent-free, meaning chemicals are never introduced. It’s just all-natural ingredients treated with simple heat, pressure and love. That’s it.

We use the best sun-grown cannabis flowers from our partner farmers in Humboldt County. Where possible, our raw ingredients and essential oils are organic, and we have deep relationships with the people from whom we source. We have assembled the best medical researchers, scientists, doctors, and holistic healers to measure, analyze, and optimize our formulations so that we can deliver the highest quality products to you and your family.

Scientific Rigor

In partnership with Israeli firms, we constantly test our products and use leading industry research to demonstrate the efficacy of cannabis for a number of ailments. We also work with a Scientific Advisory Board every step of the way.

Dr. Orrin Devinsky

brings over 35 years of expertise as a world renowned neurologist to the Papa & Barkley Scientific Advisory Board. He specializes in the treatment of epilepsy.

Dr. Rafael Gidron

serves as the founder and chairman of Israel Brain Technologies. He’s also an entrepreneur who has founded and managed technology companies in multiple disciplines, including telecommunications, nanotechnology, neurotechnology, and cleantech.

Dr. Mitch Earleywine

is a professor of psychology at the State University of New York at Albany. He received his Bachelor’s degree from Columbia University and his doctorate from Indiana University. Dr. Earleywine has published over a hundred papers in scientific journals on the topic of addiction.